Glycomimetics
Modern Synthetic Methodologies
- Publisher
- Oxford University Press
- Initial publish date
- Jan 2005
- Category
- Organic
-
Hardback
- ISBN
- 9780841238800
- Publish Date
- Jan 2005
- List Price
- $242.00
Classroom Resources
Where to buy it
Description
Modern Synthetic Methodologies Toward Glycomimetics contains 10 chapters describing the syntheses of natural and non-natural glycomimetics using modern transition metal catalyzed reactions. This book also contains several experimental details allowing the readers to get familiar with such intricate reactions using complex alkylidene carbenoids, samarium diodide, dicobalt octacarbonyl alkyne cyclotrimerization, and the like. The descriptions of biologically active carbohydrates are elegantly detailed. A new solution-phase glycopeptide synthesis using unprotected glycosyl amino acids as phase-tags is also described. Important strategies into the design of complex sialic acid C-saccharides, aryl C-glycosides, and conformationally restricted analogs of the important sialyl Lewis X are discussed. Tethering of carbohydrate residues through ester bonds and applications of the Tebbe's methylenation and either ring closing metathesis or intramolecular C-glycosidations are used to provide novel carbohydrate analogs.
About the author
Contributor Notes
Rene Roy is at Universite du Quebec a Montreal.