Craniosynostosis, the early fusion of skull sutures, is a serious abnormality of infancy and childhood. Because there are many forms of the condition, both isolated and syndromatic, proper diagnosis is essential before treatment could be carried out. Not only has surgical treatment advanced in recent years, but basic knowledge of sutural and molecular biology of craniosynostosis syndromes has recently come to light. Because dramatic changes have occurred in the field, particularly in molecular biology, this new edition has been rewritten and new chapters have been added on the growth of sutures, craniofacial surgery, and epidemiology and clinical correlations. The molecular basis of craniosynostosis, with emphasis on fibroblast growth receptors, and recent research on postnatal growth and the craniofacial complex, will be discussed in detail. Many new syndromes have been delineated the established conditions have been redefined.

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M. Michael Cohen is at Dalhousie University. Ruth E. MacLean is at Dalhousie University.

"This text is superb, very dense and detailed, containing an incredible amount of information about craniosynostosis and related genetic disorders...In summary, this is the complete text on craniosynostosis...a very impressive job."--American Journal of Medical Genetics

"This comprehensive book elegantly displays all that has been learned about craniosynostosis."Joseph G. McCarthy, M.D., Lawrence D. Bell Professor of Plastic Surgery, Director, Institute of Reconstructive Plastic Surgery, New York University Medical Center

"Michael's original book is a classic--there is no other text that approaches it. I agree that our knowledge of molecular genetics, insights into pathogenesis, and advances in our understanding of surgical treatment make a second edition timely!"--John B. Mulliken, M.D., Department of Surgery, Harvard Medical School